2. Academic Validation
  3. Isariotins E and F, spirocyclic and bicyclic hemiacetals from the entomopathogenic fungus Isaria tenuipes BCC 12625

Isariotins E and F, spirocyclic and bicyclic hemiacetals from the entomopathogenic fungus Isaria tenuipes BCC 12625

  • J Nat Prod. 2009 Apr;72(4):756-9. doi: 10.1021/np800702c.
Taridaporn Bunyapaiboonsri 1,  Seangaroon Yoiprommarat,  Kamolphan Intereya,  Pranee Rachtawee,  Nigel L Hywel-Jones,  Masahiko Isaka
Affiliations

Affiliation

  • 1 National Center for Genetic Engineering and Biotechnology (BIOTEC), Klong Luang, Pathumthani, Thailand. taridaporn@biotec.or.th
PMID: 19265430 DOI: 10.1021/np800702c
Abstract

New spirocyclic and bicyclic hemiacetals, isariotins E (1) and F (2), together with TK-57-164A (3) were isolated from the entomopathogenic fungus Isaria tenuipes BCC 12625. The absolute configuration of 3 was addressed by application of the modified Mosher's method. Isariotin F (2) exhibited activity against the malaria parasite Plasmodium falciparum K1 with an IC(50) value of 5.1 microM and cytotoxic activities against Cancer cell lines (KB, BC, and NCI-H187) and nonmalignant (Vero) cells with respective IC(50) values of 15.8, 2.4, 1.6, and 2.9 microM.

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