2. Academic Validation
  3. New imidazo[1,2-a]quinoxaline derivatives: synthesis and in vitro activity against human melanoma

New imidazo[1,2-a]quinoxaline derivatives: synthesis and in vitro activity against human melanoma

  • Eur J Med Chem. 2009 Sep;44(9):3406-11. doi: 10.1016/j.ejmech.2009.02.007.
Carine Deleuze-Masquefa 1,  Georges Moarbess,  Sonia Khier,  Nadège David,  Stéphanie Gayraud-Paniagua,  Françoise Bressolle,  Frédéric Pinguet,  Pierre-Antoine Bonnet
Affiliations

Affiliation

  • 1 EA 4215, Laboratoire de Chimie des Biomolécules et de l'Environnement, Pharmacochimie et Biomolécules, Université Montpellier I, Faculté de Pharmacie, 15 av. Charles Flahault, BP 14491, 34 093 Montpellier Cedex 5, France. carine.masquefa@univ-montp1.fr
PMID: 19278757 DOI: 10.1016/j.ejmech.2009.02.007
Abstract

New imidazo[1,2-a]quinoxaline analogues have been synthesized in good yields via a bimolecular condensation of 2-imidazole carboxylic acid, followed by a coupling with ortho-fluoroaniline and subsequent substitution on the imidazole ring by Suzuki Cross-coupling reaction using microwave assistance. Antitumor activities of these derivatives were evaluated by growth inhibition of A375 cells in vitro. All compounds exhibited high activities compared to imiquimod and fotemustine used as references.

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