2. Academic Validation
  3. Discovery of 2-(5-nitrothiazol-2-ylthio)benzo[d]thiazoles as novel c-Jun N-terminal kinase inhibitors

Discovery of 2-(5-nitrothiazol-2-ylthio)benzo[d]thiazoles as novel c-Jun N-terminal kinase inhibitors

  • Bioorg Med Chem. 2009 Apr 1;17(7):2712-7. doi: 10.1016/j.bmc.2009.02.046.
Surya K De 1,  Li-Hsing Chen,  John L Stebbins,  Thomas Machleidt,  Megan Riel-Mehan,  Russell Dahl,  Vida Chen,  Hongbin Yuan,  Elisa Barile,  Aras Emdadi,  Ria Murphy,  Maurizio Pellecchia
Affiliations

Affiliation

  • 1 Burnham Institute for Medical Research, La Jolla, CA 92037, USA.
PMID: 19282190 DOI: 10.1016/j.bmc.2009.02.046
Abstract

A new series of 2-thioether-benzothiazoles has been synthesized and evaluated for JNK inhibition. The SAR studies led to the discovery of potent, allosteric JNK inhibitors with selectivity against p38.

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