2. Academic Validation
  3. Tricyclic HIV integrase inhibitors V. SAR studies on the benzyl moiety

Tricyclic HIV integrase inhibitors V. SAR studies on the benzyl moiety

  • Bioorg Med Chem Lett. 2009 Apr 15;19(8):2263-5. doi: 10.1016/j.bmcl.2009.02.092.
Haolun Jin 1,  Sammy Metobo,  Salman Jabri,  Michael Mish,  Rachael Lansdown,  Xiaowu Chen,  Manuel Tsiang,  Matthew Wright,  Choung U Kim
Affiliations

Affiliation

  • 1 Gilead Sciences, Inc, Foster City, CA 94404, USA. hjin@gilead.com
PMID: 19285389 DOI: 10.1016/j.bmcl.2009.02.092
Abstract

SAR studies on the para-fluorobenzyl moiety of tricyclic HIV Integrase inhibitors are discussed and lead compounds with potency and PK properties comparable to raltegravir were identified.

Figures