Cytotoxic and antiplasmodial xanthones from Pentadesma butyracea

J Nat Prod. 2009 May 22;72(5):954-7. doi: 10.1021/np8005953.

Fabien Zelefack ¹, David Guilet, Nicolas Fabre, Christine Bayet, Séverine Chevalley, Silvère Ngouela, Bruno Ndjakou Lenta, Alexis Valentin, Etienne Tsamo, Marie-Geneviève Dijoux-Franca

Affiliations

Affiliation

1 UMR 5557 CNRS, Département de Pharmacognosie, Faculté de Pharmacie, Université de Lyon, 8 Avenue Rockefeller, 69373 Lyon Cedex 08, France.

PMID: 19296616 DOI: 10.1021/np8005953

Abstract

Four new Xanthones, butyraxanthones A-D (1-4), were isolated from the stem bark of Pentadesma butyracea, together with six known Xanthones (5-10) and a triterpenoid (lupeol). The structures of 1-4 were established by spectroscopic methods. Compounds 1-10 were tested in vitro for antiplasmodial activity against a Plasmodium falciparum chloroquine-resistant strain and for cytotoxicity against a human breast Cancer cell line (MCF-7). Nearly all of these Xanthones exhibited good antiplasmodial activity, and some of them also demonstrated potent cytotoxicity.

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