2. Academic Validation
  3. Ligustrazine derivatives. Part 3: Design, synthesis and evaluation of novel acylpiperazinyl derivatives as potential cerebrocardiac vascular agents

Ligustrazine derivatives. Part 3: Design, synthesis and evaluation of novel acylpiperazinyl derivatives as potential cerebrocardiac vascular agents

  • Bioorg Med Chem. 2009 Apr 15;17(8):3018-24. doi: 10.1016/j.bmc.2009.03.012.
Xian-Chao Cheng 1,  Xin-Yong Liu,  Wen-Fang Xu,  Xiu-Li Guo,  Ning Zhang,  Yu-Ning Song
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, No. 44 Wenhuaxi Road, Jinan 250012, China.
PMID: 19329327 DOI: 10.1016/j.bmc.2009.03.012
Abstract

A series of novel acylpiperazinyl Ligustrazine derivatives was designed, synthesized, and their protective effects on damaged ECV-304 cells and antiplatelet aggregation activities were evaluated. The results showed that compound E33 displayed most potential protective effects on the ECV-304 cells damaged by hydrogen peroxide, and compound E1 was found to be the most active antiplatelet aggregation agent. Structure-activity relationships were briefly discussed.

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