2. Academic Validation
  3. Protolimonoids from Melia toosendan

Protolimonoids from Melia toosendan

  • J Nat Prod. 2009 May 22;72(5):917-20. doi: 10.1021/np800669c.
Yi Shu Sang 1,  Chun Yan Zhou,  Ai Jun Lu,  Xiao Jin Yin,  Zhi Da Min,  Ren Xiang Tan
Affiliations

Affiliation

  • 1 Laboratory of Natural Products, Jiangsu Simcere Pharmaceutical R&D Company, Ltd, 699-18 Xuanwu Road, Xuanwu District, Nanjing 210042, People's Republic of China.
PMID: 19341288 DOI: 10.1021/np800669c
Abstract

Toosendanone A (1), a new euphane (tirucallane)-type triterpene bearing a five-membered ring in the side chain and the first cyclopentanyl protolimonoid, was isolated from the bark of Melia toosendan, along with two new tirucallanes, toosendanic acids A (2) and B (3). The structure and absolute configuration of compound 1 was elucidated by spectroscopic data interpretation and X-ray diffraction analysis. Compounds 1-3 were evaluated for cytotoxicity against a small panel of Cancer cell lines.

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