2. Academic Validation
  3. 1,8-Naphthyridine-3-carboxamide derivatives with anticancer and anti-inflammatory activity

1,8-Naphthyridine-3-carboxamide derivatives with anticancer and anti-inflammatory activity

  • Eur J Med Chem. 2009 Aug;44(8):3356-62. doi: 10.1016/j.ejmech.2009.03.015.
Vivek Kumar 1,  Manu Jaggi,  Anu T Singh,  Alka Madaan,  Vinod Sanna,  Pratibha Singh,  Pramod K Sharma,  Raghuveer Irchhaiya,  Anand C Burman
Affiliations

Affiliation

  • 1 Chemical Research, Dabur Research Foundation, Ghaziabad, UP, India. kumarv@dabur.com
PMID: 19361894 DOI: 10.1016/j.ejmech.2009.03.015
Abstract

A number of 1-propargyl-1,8-naphthyridine-3-carboxamide derivatives (15-35) have been synthesized and screened for their in vitro cytotoxicity and anti-inflammatory activity. Compounds 22, 31 and 34 have shown high cytotoxicity against a number of Cancer cell lines, while compound 24 showed significant anti-inflammatory activity.

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