2. Academic Validation
  3. Discovering a new analogue of thalidomide which may be used as a potent modulator of TNF-alpha production

Discovering a new analogue of thalidomide which may be used as a potent modulator of TNF-alpha production

  • Eur J Med Chem. 2009 Sep;44(9):3533-42. doi: 10.1016/j.ejmech.2009.03.018.
Miguel Fernández Braña 1,  Nuria Acero,  Loreto Añorbe,  Dolores Muñoz Mingarro,  Francisco Llinares,  Gema Domínguez
Affiliations

Affiliation

  • 1 Instituto Canario de Investigación del Cáncer, Brasil 25, 28110 Algete, Madrid, Spain. mifbrana@gmail.com
PMID: 19394719 DOI: 10.1016/j.ejmech.2009.03.018
Abstract

A new series of imide derivatives related to thalidomide were synthesized and evaluated as modulators of TNF-alpha production. These derivatives enhance TNF-alpha production using human leukemia HL-60 cells induced with 12-O-tetradecanoylphorbol 13-acetate (TPA), while inhibiting TNF-alpha production induced with okadaic acid (OA) in the same cell line. The diphenylmaleimide derivative 2f, was found to be the most active product, producing a strong modulation of the cytokine level.

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