2. Academic Validation
  3. 2-(substituted phenyl)amino analogs of 1-methoxyspirobrassinol methyl ether: synthesis and anticancer activity

2-(substituted phenyl)amino analogs of 1-methoxyspirobrassinol methyl ether: synthesis and anticancer activity

  • Bioorg Med Chem. 2009 May 15;17(10):3698-712. doi: 10.1016/j.bmc.2009.03.064.
Peter Kutschy 1,  Aneta Salayová,  Zuzana Curillová,  Tibor Kozár,  Roman Mezencev,  Ján Mojzis,  Martina Pilátová,  Eva Balentová,  Pavel Pazdera,  Marián Sabol,  Michaela Zburová
Affiliations

Affiliation

  • 1 Department of Organic Chemistry, Institute of Chemical Sciences, Faculty of Science, P.J. Safárik University, Moyzesova 11, 040 01 Kosice, Slovak Republic. peter.kutschy@upjs.sk
PMID: 19394829 DOI: 10.1016/j.bmc.2009.03.064
Abstract

New analogs of indole phytoalexin 1-methoxyspirobrassinol methyl ether have been designed by replacement of its 2-methoxy group with 2-(substituted phenyl)amino group. Synthesized by spirocyclization methodology, trans- and cis-diastereoisomers of target compounds were isolated and evaluated as potential Anticancer and antimicrobial agents. Their molecular geometries were refined by ab initio minimizations. Pharmacophore modeling and QSAR studies were performed in order to correlate their molecular structure and biological activity.

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