2. Academic Validation
  3. Novel pyridopyrimidine derivatives as inhibitors of stable toxin a (STa) induced cGMP synthesis

Novel pyridopyrimidine derivatives as inhibitors of stable toxin a (STa) induced cGMP synthesis

  • Bioorg Med Chem Lett. 2009 Jun 1;19(11):3067-71. doi: 10.1016/j.bmcl.2009.04.024.
Eric A Tanifum 1,  Alexander Y Kots,  Byung-Kwon Choi,  Ferid Murad,  Scott R Gilbertson
Affiliations

Affiliation

  • 1 Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Galveston, TX 77555-0650, USA.
PMID: 19409779 DOI: 10.1016/j.bmcl.2009.04.024
Abstract

A series of pyridopyrimidine derivatives were synthesized and evaluated for their ability to inhibit cyclic nucleotide synthesis in the presence of stable toxin a of Escherichia coli. The structure activity relationships around the basic core structure were examined and examples with better activity and potentially better pharmacological properties are presented.

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