2. Academic Validation
  3. Synthesis of yashabushidiol and its analogues and their cytotoxic activity against cancer cell lines

Synthesis of yashabushidiol and its analogues and their cytotoxic activity against cancer cell lines

  • Bioorg Med Chem Lett. 2009 Jun 1;19(11):3125-7. doi: 10.1016/j.bmcl.2009.03.061.
M Narasimhulu 1,  T Srikanth Reddy,  K Chinni Mahesh,  A Sai Krishna,  J Venkateswara Rao,  Y Venkateswarlu
Affiliations

Affiliation

  • 1 Organic Division-I, Natural Products Laboratory, Indian Institute of Chemical Technology, Hyderabad, India.
PMID: 19410455 DOI: 10.1016/j.bmcl.2009.03.061
Abstract

A total synthesis of yashabushidiol (1a), a linear diarylheptanoid having 1,3- diol system and its analogues has been achieved by alkynylation of 3-hydroxy-5-phenyl pentanal with substituted phenyl acetylenes. All the compounds have shown significant anti-proliferative activity on human leukemia (THP-1, U-937) and melanoma (A-375) cell lines. Compounds 2a and 2b were found to be most potent with an IC(50) of 12.82 microg/mL and 12.62 microg/mL, respectively, on THP-1 leukemia cell line.

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