2. Academic Validation
  3. Synthesis of pochoxime prodrugs as potent HSP90 inhibitors

Synthesis of pochoxime prodrugs as potent HSP90 inhibitors

  • Bioorg Med Chem Lett. 2009 Jul 15;19(14):3836-40. doi: 10.1016/j.bmcl.2009.04.030.
Cuihua Wang 1,  Sofia Barluenga,  Girish K Koripelly,  Jean-Gonzague Fontaine,  Ruihong Chen,  Jin-Chen Yu,  Xiaodong Shen,  John C Chabala,  James V Heck,  Allan Rubenstein,  Nicolas Winssinger
Affiliations

Affiliation

  • 1 Institute de Science et d'Ingénierie Supramoleculaires, Université de Strasbourg, Strasbourg, France.
PMID: 19410458 DOI: 10.1016/j.bmcl.2009.04.030
Abstract

Pochoximes are potent inhibitors of heat shock protein 90 (HSP90) based on the radicicol pharmacophores. Herein we present a pharmacokinetics and pharmacodynamics evaluation of this compound series as well as a phosphate prodrug strategy to facilitate formulation and improve oral bioavailability.

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