2. Academic Validation
  3. Aspochalasin I, a melanogenesis inhibitor from Aspergillus sp

Aspochalasin I, a melanogenesis inhibitor from Aspergillus sp

  • J Microbiol Biotechnol. 2009 Apr;19(4):368-71. doi: 10.4014/jmb.0806.389.
Soo-Jin Choo 1,  Bong-Sik Yun,  In-Ja Ryoo,  Young-Hee Kim,  Ki-Hwan Bae,  Ick-Dong Yoo
Affiliations

Affiliation

  • 1 Functional Metabolite Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Korea.
PMID: 19420992 DOI: 10.4014/jmb.0806.389
Abstract

In the course of screening for the melanogenesis inhibitors, aspochalasin I was isolated from solid-state culture of Aspergillus sp. Fb020460. Its structure was determined by spectroscopic analysis including mass spectroscopy and NMR analysis. Aspochalasin I potently inhibited melanogenesis in Mel-Ab cells with an IC50 value of 22.4 microM without cytotoxicity.

Figures
Products