Aspochalasin I

Cat. No.: HY-126618: FAQs
Data Sheet Handling Instructions

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Aspochalasin I exhibits cytotoxicity against cancer cells NCIH460, MCF-7 and SF-268, with IC₅₀s of 22.1, 33.4 and 19.9 μM. Aspochalasin I inhibits melanogenesis (IC₅₀ of 22.4 μM) through inhibition of tyrosinase, and can thus be used as whitening agent.

For research use only. We do not sell to patients.

Aspochalasin I Chemical Structure

CAS No. : 670225-69-1

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	33.4 μM Compound: 1, aspochalasin I	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 15043404]
NCI-H460	IC₅₀	22.1 μM Compound: 1, aspochalasin I	Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT assay Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT assay	[PMID: 15043404]
SF-268	IC₅₀	19.9 μM Compound: 1, aspochalasin I	Cytotoxicity against human SF268 cells after 48 hrs by MTT assay Cytotoxicity against human SF268 cells after 48 hrs by MTT assay	[PMID: 15043404]

Molecular Weight

417.54

Formula

C₂₄H₃₅NO₅

CAS No.

670225-69-1

SMILES

CC1=C[C@@](/C=C(C)/CC[C@H](O)[C@H](O)/C=C/2)([H])[C@@]3(OC2=O)[C@@]([C@H](CC(C)C)NC3=O)([H])[C@@H]1C

Structure Classification

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Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Choo SJ, et al., Aspochalasin I, a melanogenesis inhibitor from Aspergillus sp. J Microbiol Biotechnol. 2009 Apr;19(4):368-71 [Content Brief]

[2]. Zhou GX, et al., Aspochalasins I, J, and K: three new cytotoxic cytochalasans of Aspergillus flavipes from the rhizosphere of Ericameria laricifolia of the Sonoran Desert. J Nat Prod. 2004 Mar;67(3):328-32. [Content Brief]

Aspochalasin I Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aspochalasin I670225-69-1TyrosinaseNCIH460MCF-7SF-268Mel-Ab melanocyteInhibitorinhibitorinhibit

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