2. Academic Validation
  3. Design, synthesis and insulin-sensitizing activity of indomethacin and diclofenac derivatives

Design, synthesis and insulin-sensitizing activity of indomethacin and diclofenac derivatives

  • Bioorg Med Chem Lett. 2009 Jun 15;19(12):3324-7. doi: 10.1016/j.bmcl.2009.04.050.
Jiquan Zhang 1,  Jianta Wang,  Haoshu Wu,  Yaoyao He,  Gaofeng Zhu,  Xing Cui,  Lei Tang
Affiliations

Affiliation

  • 1 School of Pharmacy, Guiyang Medical College, Guiyang 550004, China.
PMID: 19423341 DOI: 10.1016/j.bmcl.2009.04.050
Abstract

A series of aromatic acetic acid compounds were designed and synthesized on the basis of Non-steroidal anti-inflammatory drugs indomethacin and diclofenac. Compounds 5a, 7a, 5h, 7h and 17 could strongly promote insulin-regulated differentiation of 3T3-L1 cells in vitro. They acted as full or partial PPARgamma agonist, or improved Insulin resistance through non-PPARgamma pathway.

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