2. Academic Validation
  3. ent-Kaurane diterpenoids from Isodon pharicus

ent-Kaurane diterpenoids from Isodon pharicus

  • J Nat Prod. 2009 Jun;72(6):988-93. doi: 10.1021/np9000366.
Yong Zhao 1,  Jian-Xin Pu,  Sheng-Xiong Huang,  Li-Sheng Ding,  Ying-Li Wu,  Xian Li,  Li-Bin Yang,  Wei-Lie Xiao,  Guo-Qiang Chen,  Han-Dong Sun
Affiliations

Affiliation

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.
PMID: 19425589 DOI: 10.1021/np9000366
Abstract

Phytochemical investigation of the aerial parts of Isodon pharicus led to the isolation of 13 new ent-kaurane Diterpenoids, compounds 1-13, together with 12 known analogues (14-25). The structures of the new compounds were determined by means of extensive spectroscopic techniques including interpretation of 1D and 2D NMR spectra. Selected compounds were evaluated for their cytotoxicity against NB4, A549, PC-3, MCF-7, and SH-SY5Y cell lines.

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