2. Academic Validation
  3. Semisynthesis and antiproliferative evaluation of a series of 3'-aminoflavones

Semisynthesis and antiproliferative evaluation of a series of 3'-aminoflavones

  • Bioorg Med Chem Lett. 2009 Jul 1;19(13):3502-6. doi: 10.1016/j.bmcl.2009.05.008.
Jérôme Quintin 1,  Didier Buisson,  Sylviane Thoret,  Thierry Cresteil,  Guy Lewin
Affiliations

Affiliation

  • 1 Laboratoire de Pharmacognosie, (Univ. Paris-Sud 11, BIOCIS, UMR-8076 CNRS), Faculté de Pharmacie, av. J.B. Clément, 92296 Châtenay-Malabry Cedex, France.
PMID: 19457664 DOI: 10.1016/j.bmcl.2009.05.008
Abstract

A series of 3'-aminoflavones 5,6,7,8-tetra- or 5,7-dioxygenated on the A-ring was synthesized from tangeretin or naringin, two natural Citrus Flavonoids. These Flavones were evaluated for antiproliferative activity, activation of Apoptosis, and inhibition of tubulin assembly. The most antiproliferative Flavones exhibit a common 5-hydroxy-6,7,8-trimethoxy substitution pattern on the A-ring.

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