2. Academic Validation
  3. Aminoquinoline derivatives with antiproliferative activity against melanoma cell line

Aminoquinoline derivatives with antiproliferative activity against melanoma cell line

  • Bioorg Med Chem Lett. 2009 Jul 1;19(13):3517-20. doi: 10.1016/j.bmcl.2009.05.007.
Bong Soo Nam 1,  Hwan Kim,  Chang-Hyun Oh,  So Ha Lee,  Seung Joo Cho,  Tae Bo Sim,  Jung-Mi Hah,  Dong Jin Kim,  Jung Hoon Choi,  Kyung Ho Yoo
Affiliations

Affiliation

  • 1 Life Sciences Research Division, Korea Institute of Science and Technology, PO Box 131, Cheongryang, Seoul 130-650, Republic of Korea.
PMID: 19464887 DOI: 10.1016/j.bmcl.2009.05.007
Abstract

The synthesis of a novel series of aminoquinoline derivatives 1a-p and their antiproliferative activities against A375 human melanoma cell line were described. Most compounds showed superior antiproliferative activities to Sorafenib as a reference compound. Among them, quinolinyloxymethylphenyl compounds 1k and 1l exhibited potent activities (IC(50)=0.77 and 0.79microM, respectively) and excellent selectivity against melanoma and fibroblast cell lines.

Figures