2. Academic Validation
  3. Synthesis and biological evaluation of novel 4,5-bis(dialkylaminoalkyl)-substituted acridines as potent telomeric G-quadruplex ligands

Synthesis and biological evaluation of novel 4,5-bis(dialkylaminoalkyl)-substituted acridines as potent telomeric G-quadruplex ligands

  • Eur J Med Chem. 2009 Oct;44(10):3880-8. doi: 10.1016/j.ejmech.2009.04.021.
Marie Laronze-Cochard 1,  Young-Min Kim,  Bertrand Brassart,  Jean-François Riou,  Jean-Yves Laronze,  Janos Sapi
Affiliations

Affiliation

  • 1 Université de Reims-Champagne-Ardenne, Institut de Chimie Moléculaire de Reims, CNRS UMR 6229, IFR 53 Biomolécules, Faculté de Pharmacie, 51 rue de Cognacq-Jay, F-51096 Reims, France.
PMID: 19467742 DOI: 10.1016/j.ejmech.2009.04.021
Abstract

Several 4,5-bis(dialkylaminoalkyl)-substituted acridines have been prepared starting from acridine and their telomeric G-quadruplex stabilizing properties were evaluated using FRET melting and TRAP (Telomerase Repeat Amplification Protocol Assay) experiments.

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