2. Academic Validation
  3. Two new neo-clerodane diterpenoid alkaloids from Scutellaria barbata with cytotoxic activities

Two new neo-clerodane diterpenoid alkaloids from Scutellaria barbata with cytotoxic activities

  • J Asian Nat Prod Res. 2009;11(5):451-6. doi: 10.1080/10286020902845652.
Sheng-Jun Dai 1,  Wei-Bing Peng,  Li Shen,  De-Wu Zhang,  Yan Ren
Affiliations

Affiliation

  • 1 School of Pharmaceutical Science, Yantai University, Yantai, China. daishengjun_9@hotmail.com
PMID: 19504388 DOI: 10.1080/10286020902845652
Abstract

Two new neo-clerodane diterpenoid Alkaloids, scutebarbatine O (1) and 6-O-nicotinoylscutebarbatine G (2), were isolated from the whole plant of Scutellaria barbata. Their structures were elucidated by spectroscopic methods including extensive 1D and 2D NMR analyses. In vitro, compounds 1 and 2 showed cytotoxic activities against three human tumor cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and with IC(50) values in the range of 2.1-5.7 microM.

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