1. Academic Validation
  2. Structure, activities and biomedical applications of human butyrylcholinesterase

Structure, activities and biomedical applications of human butyrylcholinesterase

  • Protein Pept Lett. 2009;16(10):1215-24. doi: 10.2174/092986609789071207.
Patrick Masson 1 Eugénie Carletti Florian Nachon
Affiliations

Affiliation

  • 1 Centre de Recherches du Service de Santé des Armées, Department of Toxicology, Enzymology Unit, BP 87, 38702 La Tronche cedex, France. pmasson@unmc.edu
Abstract

Human butyrylcholinesterase (BuChE) is a serine Enzyme present in most organs and plasma. No clear physiological function has yet been assigned to BuChE, but it is a pharmacologically and toxicologically important Enzyme that plays a role in degradation of numerous ester-containing drugs and poisonous esters. Thus, BuChE-based bioscavengers are an alternative for prophylaxis and treatments of intoxications by these compounds. Also, BuChE has been integrated in biosensors for detection of organophosphorus compounds and other cholinesterase inhibitors.

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