2. Academic Validation
  3. Cyclin Y, a novel membrane-associated cyclin, interacts with PFTK1

Cyclin Y, a novel membrane-associated cyclin, interacts with PFTK1

  • FEBS Lett. 2009 Jul 7;583(13):2171-8. doi: 10.1016/j.febslet.2009.06.010.
Mei Jiang 1,  Yankun Gao,  Tao Yang,  Xueliang Zhu,  Jiangye Chen
Affiliations

Affiliation

  • 1 State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, SIBS, Chinese Academy of Sciences, Shanghai, China.
PMID: 19524571 DOI: 10.1016/j.febslet.2009.06.010
Abstract

A novel cyclin, CCNY, was identified as a PFTK1 interacting protein in a yeast two-hybrid screen. The cyclin box in CCNY and the PFTAIRE motif in PFTK1 are both required for the interaction which was confirmed by in vivo and in vitro assays. Two transcripts (4 and 2kb), of CCNY were detected by Northern blot analysis and CCNY was enriched at the plasma membrane due to an N-terminal myristoylation signal. We propose that binding of CCNY to PFTK1 enhances PFTK1 kinase activity and changes its intracellular location.

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