The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans

J Exp Med. 2009 Jul 6;206(7):1495-503. doi: 10.1084/jem.20090681.

Cameron S Brandt ¹, Myriam Baratin, Eugene C Yi, Jacob Kennedy, Zeren Gao, Brian Fox, Betty Haldeman, Craig D Ostrander, Tomonori Kaifu, Christian Chabannon, Alessandro Moretta, Robert West, Wenfeng Xu, Eric Vivier, Steven D Levin

Affiliations

Affiliation

1 Molecular and Cell Based Discovery, ZymoGenetics Inc., Seattle, WA 98102, USA.

PMID: 19528259 DOI: 10.1084/jem.20090681

Abstract

Cancer development is often associated with the lack of specific and efficient recognition of tumor cells by the immune system. Natural killer (NK) cells are lymphocytes of the innate immune system that participate in the elimination of tumors. We report the identification of a tumor cell surface molecule that binds NKp30, a human receptor which triggers antitumor NK cell cytotoxicity and cytokine secretion. This previously unannotated gene belongs to the B7 family and, hence, was designated B7-H6. B7-H6 triggers NKp30-mediated activation of human NK cells. B7-H6 was not detected in normal human tissues but was expressed on human tumor cells, emphasizing that the expression of stress-induced self-molecules associated with cell transformation serves as a mode of cell recognition in innate immunity.

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