2. Academic Validation
  3. Anti-inflammatory activity of Flavokawain B from Alpinia pricei Hayata

Anti-inflammatory activity of Flavokawain B from Alpinia pricei Hayata

  • J Agric Food Chem. 2009 Jul 22;57(14):6060-5. doi: 10.1021/jf900517d.
Chien-Tsong Lin 1,  K Jayabal Senthil Kumar,  Yen-Hsueh Tseng,  Zi-Jie Wang,  Mu-Yun Pan,  Jun-Hong Xiao,  Shih-Chang Chien,  Sheng-Yang Wang
Affiliations

Affiliation

  • 1 Department of Forestry, National Chung-Hsing University, Taichung 402, Taiwan.
PMID: 19537711 DOI: 10.1021/jf900517d
Abstract

Alpinia pricei (Zingiberaceae) is a spicy herb indigenous to Taiwan. A potent anti-inflammatory compound, flavokawain B (FKB), was obtained from A. pricei. FKB significantly inhibited production of NO and PGE(2) in LPS-induced RAW 264.7 cells. Moreover, it also notably decreased the secretion of TNF-alpha. Expression of iNOS and COX-2 proteins was also inhibited by FKB in a dose-dependent manner. FKB blocked the nuclear translocation of NF-kappaB induced by LPS, which was associated with prevention IkappaB degradation, and subsequently decreased NF-kappaB protein levels in the nucleus. Similar anti-inflammatory activities of FKB were observed in an animal assay. NO concentrations in mouse serum rose dramatically from 3.2 to 28.8 microM after mice were challenged with LPS; however, preadministration of 200 mg/kg FKB reduced the NO concentration to 3.8 microM after challenge with LPS. Moreover, FKB strongly suppressed LPS-induced iNOS, COX-2, and NF-kappaB proteins expression in mouse liver.

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