2. Academic Validation
  3. Monoamine levels in rat striatum after acute intraperitoneal injection of strictosidinic acid isolated from Psychotria myriantha Mull. Arg. (Rubiaceae)

Monoamine levels in rat striatum after acute intraperitoneal injection of strictosidinic acid isolated from Psychotria myriantha Mull. Arg. (Rubiaceae)

  • Phytomedicine. 2010 Mar;17(3-4):289-91. doi: 10.1016/j.phymed.2009.05.008.
F M Farias 1,  C S Passos,  M D Arbo,  J A S Zuanazzi,  V M Steffen,  A T Henriques
Affiliations

Affiliation

  • 1 Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul. Av. Ipiranga, 2752, CEP 90610-000 Porto Alegre, RS, Brazil.
PMID: 19576739 DOI: 10.1016/j.phymed.2009.05.008
Abstract

Strictosidinic acid 10mg/kg, isolated from Psychotria myriantha leaves, were administered intraperitoneally to Wistar male rats (n=5-6). After 60 minutes, striatum was dissected, homogenized and injected onto HPLC-ED chromatographic system. It was observed a 28.7% reduction in the 5-HT levels followed up by an increase of 5-HIAA levels (29.4%). Furthermore there was a decrease of 8.0% in DA levels and an increase in the levels of metabolites DOPAC (21.5%) and HVA (52.5%). The results indicate that strictosidinic acid has a promising effect in the central nervous system, justifying more studies about the central actions of Psychotria compounds.

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