2. Academic Validation
  3. Discovery of CYT997: a structurally novel orally active microtubule targeting agent

Discovery of CYT997: a structurally novel orally active microtubule targeting agent

  • Bioorg Med Chem Lett. 2009 Aug 15;19(16):4639-42. doi: 10.1016/j.bmcl.2009.06.079.
Christopher J Burns 1,  Michael F Harte,  Xianyong Bu,  Emmanuelle Fantino,  Max Joffe,  Harrison Sikanyika,  Stephen Su,  C Elisabet Tranberg,  Neil Wilson,  Susan A Charman,  David M Shackleford,  Andrew F Wilks
Affiliations

Affiliation

  • 1 Cytopia Research Pty Ltd, Richmond, VIC 3121, Australia.
PMID: 19616947 DOI: 10.1016/j.bmcl.2009.06.079
Abstract

CYT997 was discovered as a potent tubulin polymerization inhibitor possessing potent cytotoxic activity against a range of Cancer cells. Details of SAR studies, pharmacokinetic investigations and synthesis of compounds leading to the discovery of CYT997 are reported.

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