2. Academic Validation
  3. Design, synthesis, and structure-activity relationships of 1,3-dihydrobenzimidazol-2-one analogues as anti-HIV agents

Design, synthesis, and structure-activity relationships of 1,3-dihydrobenzimidazol-2-one analogues as anti-HIV agents

  • Bioorg Med Chem. 2009 Aug 15;17(16):5962-7. doi: 10.1016/j.bmc.2009.06.068.
Anna-Maria Monforte 1,  Patrizia Logoteta,  Stefania Ferro,  Laura De Luca,  Nunzio Iraci,  Giovanni Maga,  Erik De Clercq,  Christophe Pannecouque,  Alba Chimirri
Affiliations

Affiliation

  • 1 Dipartimento Farmaco-Chimico, Università di Messina, Italy. ammonforte@pharma.unime.it
PMID: 19616956 DOI: 10.1016/j.bmc.2009.06.068
Abstract

Non-nucleoside Reverse Transcriptase inhibitors (NNRTIs) have become very important components in the antiretroviral combination therapies used to treat HIV. Recently, our group identified some 1,3-dihydrobenzimidazol-2-one derivatives and their sulfones as a potent and novel class of NNRTIs. We herein report the synthesis and biological evaluation of the new compounds in which different structural modifications have been introduced in order to investigate their effects on RT inhibition.

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