2. Academic Validation
  3. Prenylxanthones and a bicyclo[3.3.1]nona-2,6-diene derivative from the fungus Emericella rugulosa

Prenylxanthones and a bicyclo[3.3.1]nona-2,6-diene derivative from the fungus Emericella rugulosa

  • J Nat Prod. 2009 Aug;72(8):1442-6. doi: 10.1021/np800805f.
Panawan Moosophon 1,  Somdej Kanokmedhakul,  Kwanjai Kanokmedhakul,  Kasem Soytong
Affiliations

Affiliation

  • 1 Natural Products Research Unit, Department of Chemistry, and Center for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
PMID: 19627125 DOI: 10.1021/np800805f
Abstract

Five new prenylxanthones, ruguloxanthones A-C (1-3), 14-methoxytajixanthone (4), and tajixanthone ethanoate (5), a new bicyclo[3.3.1]nona-2,6-diene derivative, rugulosone (6), and seven known compounds, shamixanthone, tajixanthone, 14-methoxytajixanthone-25-acetate, tajixanthone hydrate, tajixanthone methanoate, isoemericellin, and ergosterol, were isolated from the fungus Emericella rugulosa. The structures of 1-6 were established using spectroscopic techniques. Compound 6 exhibited antimalarial and antimycobacterial activities, as well as cytotoxicity against three Cancer cell lines.

Figures