2. Academic Validation
  3. Synthesis and biological evaluation of asymmetric gramicidin S analogues containing modified D-phenylalanine residues

Synthesis and biological evaluation of asymmetric gramicidin S analogues containing modified D-phenylalanine residues

  • Bioorg Med Chem. 2009 Sep 1;17(17):6318-28. doi: 10.1016/j.bmc.2009.07.042.
Matthijs van der Knaap 1,  Eefje Engels,  Henk J Busscher,  José M Otero,  Antonio L Llamas-Saiz,  Mark J van Raaij,  Roos H Mars-Groenendijk,  Daan Noort,  Gijsbert A van der Marel,  Herman S Overkleeft,  Mark Overhand
Affiliations

Affiliation

  • 1 Bio-Organic Synthesis, Leiden Institute of Chemistry, University of Leiden, Leiden, The Netherlands.
PMID: 19674904 DOI: 10.1016/j.bmc.2009.07.042
Abstract

The synthesis of new analogues of the cationic antimicrobial peptide gramicidin S, having a modified D-phenylalanine residue, their Antibacterial properties against several gram positive and negative strains, as well as their hemolytic activity is reported.

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