2. Academic Validation
  3. Design, synthesis, and biological activity of a family of novel ceramide analogues in chemoresistant breast cancer cells

Design, synthesis, and biological activity of a family of novel ceramide analogues in chemoresistant breast cancer cells

  • J Med Chem. 2009 Sep 24;52(18):5748-52. doi: 10.1021/jm9009668.
James W Antoon 1,  Jiawang Liu,  Matthew M Gestaut,  Matthew E Burow,  Barbara S Beckman,  Maryam Foroozesh
Affiliations

Affiliation

  • 1 Department of Pharmacology and Department of Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, Louisiana 70112, USA.
PMID: 19694470 DOI: 10.1021/jm9009668
Abstract

Resistance to chemotherapy and endocrine therapy is a major cause of breast Cancer treatment failure. We have synthesized six novel analogues using C8-ceramide as the lead analogue and studied their effect on hormone therapy resistant (MDA-MB-231) and chemoresistant (MCF-7TN-R) breast Cancer cells. Pharmacologic intervention using these ceramide analogues inhibited clonogenic survival and induced Apoptosis, with one analogue being more effective than C8-ceramide. Our results show ceramide-based therapy has therapeutic potential in treating drug resistant breast Cancer.

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