2. Academic Validation
  3. Antidiarrhoeal activity of carbazole alkaloids from Murraya koenigii Spreng (Rutaceae) seeds

Antidiarrhoeal activity of carbazole alkaloids from Murraya koenigii Spreng (Rutaceae) seeds

  • Fitoterapia. 2010 Jan;81(1):72-4. doi: 10.1016/j.fitote.2009.08.016.
Suvra Mandal 1,  Anupam Nayak,  Manoj Kar,  Samir K Banerjee,  Ashes Das,  S N Upadhyay,  R K Singh,  Avijit Banerji,  Julie Banerji
Affiliations

Affiliation

  • 1 Department of Chemistry, National Research Institute of Ayurveda for Drug Development, Bidhannagar, Kolkata - 700091, India.
PMID: 19695314 DOI: 10.1016/j.fitote.2009.08.016
Abstract

The bioassay guided fractionation of the n-hexane extract of the seeds of Murraya koenigii Spreng (Rutaceae) resulted in the isolation of three bioactive Carbazole Alkaloids, kurryam (I), koenimbine (II) and koenine (III). The structures of the compounds were confirmed from their (1)H-, (13)C-, and 2D-NMR spectral data. Of the three compounds (I) and (II) exhibited significant inhibitory activity against castor oil-induced diarrhoea and PGE(2)-induced enteropooling in rats. The compounds also produced a significant reduction in gastrointestinal motility in the charcoal meal test in Wistar rats.

Figures
Products