2. Academic Validation
  3. O-Spiro C-aryl glucosides as novel sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors

O-Spiro C-aryl glucosides as novel sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors

  • Bioorg Med Chem Lett. 2009 Oct 1;19(19):5632-5. doi: 10.1016/j.bmcl.2009.08.030.
Baihua Xu 1,  Binhua Lv,  Yan Feng,  Ge Xu,  Jiyan Du,  Ajith Welihinda,  Zelin Sheng,  Brian Seed,  Yuanwei Chen
Affiliations

Affiliation

  • 1 Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, Sichuan 610041, PR China. xubaihua2002@163.com
PMID: 19700318 DOI: 10.1016/j.bmcl.2009.08.030
Abstract

Two series of O-spiro C-aryl glucosides were synthesized and tested for inhibition of hSGLT1 and hSGLT2. 6'-O-Spiro C-aryl glucosides exhibited potent in vitro hSGLT2 inhibitory activity but 2'-O-spiro C-aryl glucosides showed no in vitro hSGLT2 inhibitory activity at a screening concentration of 1microM.

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