2. Academic Validation
  3. Antiprotozoal activity of betulinic acid derivatives

Antiprotozoal activity of betulinic acid derivatives

  • Phytomedicine. 2010 Apr;17(5):379-82. doi: 10.1016/j.phymed.2009.08.002.
D B Domínguez-Carmona 1,  F Escalante-Erosa,  K García-Sosa,  G Ruiz-Pinell,  D Gutierrez-Yapu,  M J Chan-Bacab,  A Giménez-Turba,  L M Peña-Rodríguez
Affiliations

Affiliation

  • 1 Unidad de Biotecnología, Centro de Investigación Científica de Yucatán, Calle 43, No. 130, Col. Chuburná, Mérida, Yucatán 97200, México.
PMID: 19748254 DOI: 10.1016/j.phymed.2009.08.002
Abstract

Betulinic acid (1), isolated from the crude extract of the leaves of Pentalinon andrieuxii (Apocynaceae), together with betulinic acid acetate (2), betulonic acid (3), betulinic acid methyl ester (4), and betulin (5) were evaluated for their antiprotozoal activity. The results showed that modifying the C-3 position increases leishmanicidal activity while modification of the C-3 and C-28 positions decreases trypanocidal activity.

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