2. Academic Validation
  3. Identification of antiadipogenic constituents of the rhizomes of Anemarrhena asphodeloides

Identification of antiadipogenic constituents of the rhizomes of Anemarrhena asphodeloides

  • J Nat Prod. 2009 Oct;72(10):1895-8. doi: 10.1021/np900397f.
Ui Joung Youn 1,  Ye Seul Lee,  Hana Jeong,  Jun Lee,  Joo-Won Nam,  Yoo Jin Lee,  Eun Sook Hwang,  Je-Hyun Lee,  Dongho Lee,  Sam Sik Kang,  Eun-Kyoung Seo
Affiliations

Affiliation

  • 1 The Center for Cell Signaling & Drug Discovery Research, College of Pharmacy, Ewha Womans University, Seoul 120-750, Korea.
PMID: 19757853 DOI: 10.1021/np900397f
Abstract

Three new phenolic compounds, (E)-4'-demethyl-6-methyleucomin (1), anemarcoumarin A (2), and anemarchalconyn (3), were isolated from an ethyl acetate extract of the rhizomes of Anemarrhena asphodeloides, together with seven known compounds (4-10). The structures of the new compounds (1-3) were determined on the basis of spectroscopic data interpretation. Compound 3 exhibited a potent inhibitory effect against the differentiation of preadipocyte 3T3-L1 cells with an IC50 value of 5.3 microM.

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