2. Academic Validation
  3. Cytotoxic clerodane diterpenoids from Casearia obliqua

Cytotoxic clerodane diterpenoids from Casearia obliqua

  • J Nat Prod. 2009 Oct;72(10):1847-50. doi: 10.1021/np9004079.
Gerardo Magela Vieira Jr 1,  Tiago de Oliveira Gonçalves,  Luis O Regasini,  Paulo M Pinheiro Ferreira,  Cláudia do O Pessoa,  Letícia V Costa Lotufo,  Roseli Buzanelli Torres,  Nivaldo Boralle,  Vanderlan da Silva Bolzani,  Alberto José Cavalheiro
Affiliations

Affiliation

  • 1 Institute of Chemistry, Nuclei of Bioassay, Biosynthesis and Ecophysiology of Natural Products (NuBBE), São Paulo State University, UNESP, Araraquara, SP, Brazil, CP 355, CEP 14801-97.
PMID: 19788290 DOI: 10.1021/np9004079
Abstract

A crude bioactive EtOH extract of the twigs of Casearia obliqua afforded two new clerodane diterpenes, caseobliquins A (1) and B (2). Additionally, bioactivity-directed fractionation on a bioactive hexane extract of the leaves from this species led to the isolation of the known clerodane diterpenes rel-6beta-hydroxyzuelanin-2beta-benzoate and rel-2alpha-hydroxyzuelanin-6beta-benzoate (3 and 4) as a mixture and 2beta-hydroxyzuelanin-6beta-cinnamate (5). The structures of the new clerodanes 1 and 2 were established on the basis of their 1D and 2D NMR spectroscopic data, and the new compound 1 and the known substance 5 had their absolute configurations determined by circular dichroism spectroscopy. The cytotoxicity of several of the compounds isolated was evaluated against a small panel of human tumor cell lines.

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