2. Academic Validation
  3. Synthesis of isoquinolinone-based tetracycles as poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors

Synthesis of isoquinolinone-based tetracycles as poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors

  • Bioorg Med Chem. 2009 Nov 1;17(21):7537-41. doi: 10.1016/j.bmc.2009.09.014.
Hee-Kyung Rhee 1,  So Yun Lim,  Mi-Ja Jung,  Youngjoo Kwon,  Myung-Hwa Kim,  Hea-Young Park Choo
Affiliations

Affiliation

  • 1 Department of Biological Science, Sookmyung Women's University, Seoul, Republic of Korea.
PMID: 19800803 DOI: 10.1016/j.bmc.2009.09.014
Abstract

The isoquinolinone-based tetracyclic compounds were designed and synthesized and their PARP-1 inhibitory activity was evaluated. Most of synthesized compounds showed fairly good activity. Also the most active compound 6 showed its activity on potentiation of Anticancer agents, temozolamide and etoposide, by 1.7 times, respectively.

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