2. Academic Validation
  3. Optimization of azepanone calcitonin gene-related peptide (CGRP) receptor antagonists: development of novel spiropiperidines

Optimization of azepanone calcitonin gene-related peptide (CGRP) receptor antagonists: development of novel spiropiperidines

  • Bioorg Med Chem Lett. 2009 Nov 15;19(22):6368-72. doi: 10.1016/j.bmcl.2009.09.066.
Christopher S Burgey 1,  Craig M Potteiger,  James Z Deng,  Scott D Mosser,  Christopher A Salvatore,  Sean Yu,  Shane Roller,  Stefanie A Kane,  Joseph P Vacca,  Theresa M Williams
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA. christopher_burgey@merck.com
PMID: 19818613 DOI: 10.1016/j.bmcl.2009.09.066
Abstract

Several novel spiropiperidine-based CGRP Receptor antagonists have been developed that maintain good potency and have reduced potential for metabolism.

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