2. Academic Validation
  3. Bioactive constituents of the stem bark of Mitrephora glabra

Bioactive constituents of the stem bark of Mitrephora glabra

  • J Nat Prod. 2009 Nov;72(11):1949-53. doi: 10.1021/np900572g.
Chen Li 1,  Dongho Lee,  Tyler N Graf,  Sharnelle S Phifer,  Yuka Nakanishi,  Soedarsono Riswan,  Fransisca M Setyowati,  Achmad M Saribi,  Djaja D Soejarto,  Norman R Farnsworth,  Joseph O Falkinham 3rd,  David J Kroll,  A Douglas Kinghorn,  Mansukh C Wani,  Nicholas H Oberlies
Affiliations

Affiliation

  • 1 Natural Products Laboratory, Research Triangle Institute, P.O. Box 12194, Research Triangle Park, North Carolina 27709-2194, USA.
PMID: 19874044 DOI: 10.1021/np900572g
Abstract

Bioactivity-guided fractionation of the stem bark of Mitrephora glabra yielded nine compounds, comprising three ent-kaurenoids (1-3), five polyacetylenic acids/esters (4-8), and one aporphine alkaloid, liriodenine (9). The structures of the six new compounds (1-3, 5, 7, and 8) were determined by spectroscopic data interpretation. All compounds were evaluated for their inhibitory activities against a panel of Cancer cell lines and a battery of Microorganisms.

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