2. Academic Validation
  3. Synthesis and evaluation of a thio analogue of duocarmycin SA

Synthesis and evaluation of a thio analogue of duocarmycin SA

  • Bioorg Med Chem Lett. 2009 Dec 15;19(24):6962-5. doi: 10.1016/j.bmcl.2009.10.063.
Karen S MacMillan 1,  James P Lajiness,  Carlota Lopez Cara,  Romeo Romagnoli,  William M Robertson,  Inkyu Hwang,  Pier Giovanni Baraldi,  Dale L Boger
Affiliations

Affiliation

  • 1 Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
PMID: 19879753 DOI: 10.1016/j.bmcl.2009.10.063
Abstract

The design, synthesis, and preliminary evaluation of methyl 1,2,8,8a-tetrahydrocyclopropa[c]thieno[3,2-e]indol-4-one-6-carboxylate (CTI) derivatives are detailed representing a single atom change (N to S) embedded in the duocarmycin SA alkylation subunit.

Figures
Products