2. Academic Validation
  3. Synthesis and antimycobacterial evaluation of novel 5,6-dimethoxy-1-oxo-2,5-dihydro-1H-2-indenyl-5,4-substituted phenyl methanone analogues

Synthesis and antimycobacterial evaluation of novel 5,6-dimethoxy-1-oxo-2,5-dihydro-1H-2-indenyl-5,4-substituted phenyl methanone analogues

  • Bioorg Med Chem Lett. 2009 Dec 15;19(24):7000-2. doi: 10.1016/j.bmcl.2009.10.034.
Mohamed Ashraf Ali 1,  Jeyabalan Govinda Samy,  Elumalai Manogaran,  Velmurugan Sellappan,  Mohamed Zaheen Hasan,  Mohamed Jawed Ahsan,  Suresh Pandian,  Mohammad ShaharYar
Affiliations

Affiliation

  • 1 New Drug Discovery Research, Department of Medicinal Chemistry, Alwar Pharmacy College, Alwar, Rajasthan 301 030, India. asraf80med@rediffmail.com
PMID: 19879757 DOI: 10.1016/j.bmcl.2009.10.034
Abstract

In present investigation, a series of substituted phenyl-5,6-dimethoxy-1-oxo-2,5-dihydro-1H-2-indenylmethanone analogues were synthesized and were evaluated for antimycobacterial activity against Mycobacterium tuberculosis H(37)Rv and INH resistant M. tuberculosis. All the newly synthesized compounds were showing moderate to high inhibitory activities. The compound 5,6-dimethoxy-1-oxo-2,5-dihydro-1H-2-indenyl-4-fluorophenylmethanone (5g) was found to be the most promising compounds active against M. tuberculosis H(37)Rv and isoniazid (INH) resistant M. tuberculosis with Minimum inhibitory concentration 0.10 and 0.10 microM.

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