2. Academic Validation
  3. Cytotoxic constituents of the lichen Diploicia canescens

Cytotoxic constituents of the lichen Diploicia canescens

  • J Nat Prod. 2009 Dec;72(12):2177-80. doi: 10.1021/np9003728.
Marion Millot 1,  Sophie Tomasi,  Elisabeth Studzinska,  Isabelle Rouaud,  Joël Boustie
Affiliations

Affiliation

  • 1 EA 4090 Substances Licheniques et Photoprotection, UFR des Sciences Pharmaceutiques et Biologiques, Universite de Rennes 1, 2 Avenue du Professeur Leon Bernard, 35043 Rennes Cedex, France.
PMID: 19919064 DOI: 10.1021/np9003728
Abstract

A new diphenyl ether (1), along with 12 known compounds, was isolated from the Lichen Diploicia canescens. The structure of compound 1 was elucidated by spectroscopic data analysis, and the biosynthetic origin of this product is discussed. Secalonic acids B (7), D (8), and F (9) were isolated for the first time from D. canescens. The cytotoxic activities of 1-3, 6-8, and 10 against the B16 murine melanoma and HaCaT human keratinocyte cell lines were evaluated.

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