2. Academic Validation
  3. Pyrrolidinones from the ascomycete fungus Albonectria rigidiuscula

Pyrrolidinones from the ascomycete fungus Albonectria rigidiuscula

  • J Nat Prod. 2009 Dec;72(12):2184-7. doi: 10.1021/np900619z.
Jian Li 1,  Shuchun Liu,  Shubin Niu,  Wenying Zhuang,  Yongsheng Che
Affiliations

Affiliation

  • 1 Key Laboratory of Systematic Mycology & Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.
PMID: 19919065 DOI: 10.1021/np900619z
Abstract

The new pyrrolidinones, rigidiusculamides A-D (1-4), have been isolated from the crude extract of the ascomycete fungus Albonectria rigidiuscula. The structures of these compounds were elucidated primarily by NMR experiments. The absolute configuration of the 3,4-diol moieties in 1 and 4 was assigned using Snatzke's method. Compounds 1 and 2 showed modest cytotoxicity against the human tumor cell lines HeLa and MCF-7.

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