2. Academic Validation
  3. Diterpenes, sesquiterpenes, and a sesquiterpene-coumarin conjugate from Jatropha integerrima

Diterpenes, sesquiterpenes, and a sesquiterpene-coumarin conjugate from Jatropha integerrima

  • J Nat Prod. 2009 Nov;72(11):2024-7. doi: 10.1021/np900342b.
Somyote Sutthivaiyakit 1,  Wantana Mongkolvisut,  Samran Prabpai,  Palangpon Kongsaeree
Affiliations

Affiliation

  • 1 Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand. s_somyote@ru.ac.th
PMID: 19943622 DOI: 10.1021/np900342b
Abstract

Five new compounds, 2alpha-hydroxyjatropholone (1), 2beta-hydroxyjatropholone (2), 1,5-dioxo-2,3-dihydroxyrhamnofola-4(10),6,11(18),15-tetraene (3), 2-keto-5-hydroxyguai-3,11-diene (4), and a sesquiterpene-coumarin conjugate, jatrophadioxan (5), and nine known compounds have been isolated from the roots of Jatropha integerrima. The structures were established from spectroscopic data, and the relative configuration of 1 was confirmed by X-ray crystallography. Six diterpenes were evaluated for their antiplasmodial, antituberculosis, and cytotoxic activities.

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