2. Academic Validation
  3. Novel quinolines and pyrimido[4,5-b]quinolines bearing biologically active sulfonamide moiety as a new class of antitumor agents

Novel quinolines and pyrimido[4,5-b]quinolines bearing biologically active sulfonamide moiety as a new class of antitumor agents

  • Eur J Med Chem. 2010 Feb;45(2):738-44. doi: 10.1016/j.ejmech.2009.11.021.
Saleh I Alqasoumi 1,  Areej M Al-Taweel,  Ahmed M Alafeefy,  Eman Noaman,  Mostafa M Ghorab
Affiliations

Affiliation

  • 1 Medicinal, Aromatic and Poisonous Plants Research Center, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia.
PMID: 19944497 DOI: 10.1016/j.ejmech.2009.11.021
Abstract

Some novel quinolines and pyrimido[4,5-b]quinolines have been synthesized. The structures of which were confirmed by elemental analyses and spectral data. All the target compounds were subjected to in-vitro antitumor activity against Ehrlich Ascites Carcinoma (EAC) cells. Compounds 24, 19 and 12 showed higher activity with IC(50) values (5.5, 6.9, 7 microg/ml) when compared with Doxorubicin as a reference drug (IC(50) value 38 microg/ml).

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