2. Academic Validation
  3. Synthesis and evaluation of 3'-azido-2',3'-dideoxypurine nucleosides as inhibitors of human immunodeficiency virus

Synthesis and evaluation of 3'-azido-2',3'-dideoxypurine nucleosides as inhibitors of human immunodeficiency virus

  • Bioorg Med Chem Lett. 2010 Jan 1;20(1):60-4. doi: 10.1016/j.bmcl.2009.11.031.
Hong-Wang Zhang 1,  Steven J Coats,  Lavanya Bondada,  Franck Amblard,  Mervi Detorio,  Ghazia Asif,  Emilie Fromentin,  Sarah Solomon,  Aleksandr Obikhod,  Tony Whitaker,  Nicolas Sluis-Cremer,  John W Mellors,  Raymond F Schinazi
Affiliations

Affiliation

  • 1 Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Veterans Affairs Medical Center, Atlanta, GA 30033, USA.
PMID: 19948402 DOI: 10.1016/j.bmcl.2009.11.031
Abstract

Based on the promising drug resistance profile and potent anti-HIV activity of beta-d-3'-azido-2',3'-dideoxyguanosine, a series of purine modified nucleosides were synthesized by a chemical transglycosylation reaction and evaluated for their Antiviral activity, cytotoxicity, and intracellular metabolism. Among the synthesized compounds, several show potent and selective anti-HIV activity in primary lymphocytes.

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