2. Academic Validation
  3. 3-(3-Aryloxyaryl)imidazo[1,2-a]pyridine sulfones as liver X receptor agonists

3-(3-Aryloxyaryl)imidazo[1,2-a]pyridine sulfones as liver X receptor agonists

  • Bioorg Med Chem Lett. 2010 Jan 15;20(2):521-5. doi: 10.1016/j.bmcl.2009.11.098.
Robert R Singhaus 1,  Ronald C Bernotas,  Robert Steffan,  Edward Matelan,  Elaine Quinet,  Ponnal Nambi,  Irene Feingold,  Christine Huselton,  Anna Wilhelmsson,  Annika Goos-Nilsson,  Jay Wrobel
Affiliations

Affiliation

  • 1 Chemical Sciences, Wyeth Pharmaceuticals, 500 Arcola Rd., Collegeville, PA 19426, USA. Singhar@wyeth.com
PMID: 20005711 DOI: 10.1016/j.bmcl.2009.11.098
Abstract

Replacement of a quinoline with an imidazo[1,2-a]pyridine in a series of liver X receptor (LXR) agonists incorporating a [3-(sulfonyl)aryloxyphenyl] side chain provided high affinity LXR ligands 7. In functional assays of LXR activity, good agonist potency and efficacy were found for several analogs.

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