2. Academic Validation
  3. Stolonoxides E and F, cytotoxic metabolites from the marine ascidian Stolonica socialis

Stolonoxides E and F, cytotoxic metabolites from the marine ascidian Stolonica socialis

  • J Nat Prod. 2010 Jan;73(1):83-5. doi: 10.1021/np900700h.
Fernando Reyes 1,  Raquel Rodríguez-Acebes,  Rogelio Fernández,  Santiago Bueno,  Andrés Francesch,  Carmen Cuevas
Affiliations

Affiliation

  • 1 Medicinal Chemistry Department, PharmaMar S.A.U., Pol. Ind. La Mina Norte, Avenida de los Reyes 1, 28770-Colmenar Viejo, Madrid, Spain. jfreyes@pharmamar.com
PMID: 20014800 DOI: 10.1021/np900700h
Abstract

Two new members of the stolonoxide family, stolonoxides E (1) and F (2), were isolated from samples of the marine ascidian Stolonica socialis collected in Cádiz (Spain). Their structures were determined by a combination of techniques, including (+)-HRESIMS, 1D and 2D NMR spectroscopy, and comparison with published data for the structurally related stolonoxides A-D (3-6). Both compounds displayed cytotoxicity against a panel of three human tumor cell lines.

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