2. Academic Validation
  3. Design and synthesis of novel bis-oximinoalkanoic acids as potent PPAR alpha agonists

Design and synthesis of novel bis-oximinoalkanoic acids as potent PPAR alpha agonists

  • Bioorg Med Chem Lett. 2010 Feb 1;20(3):1156-61. doi: 10.1016/j.bmcl.2009.12.022.
Harikishore Pingali 1,  Mukul Jain,  Shailesh Shah,  Pandurang Zaware,  Pankaj Makadia,  Suresh Pola,  Baban Thube,  Darshit Patel,  Pravin Patil,  Priyanka Priyadarshini,  Dinesh Suthar,  Maanan Shah,  Suresh Giri,  Pankaj Patel
Affiliations

Affiliation

  • 1 Zydus Research Centre, Sarkhej-Bavla NH 8A Moraiya, Ahmedabad 382 210, India. pingalihk@rediffmail.com
PMID: 20022492 DOI: 10.1016/j.bmcl.2009.12.022
Abstract

Bis-oximinoalkanoic acid derivatives were designed and synthesized to aid in the characterization of selective PPARalpha agonists by replacing the oxazole ring with flexible oximino group in the lipophilic tail part of a previously reported compound 3. Selected compounds 9d and 9m showed excellent potency and high selectivity towards PPARalpha in vitro. These compounds found effective in reducing serum triglycerides (TG) in vivo.

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