2. Academic Validation
  3. Oblongolides from the endophytic fungus Phomopsis sp. BCC 9789

Oblongolides from the endophytic fungus Phomopsis sp. BCC 9789

  • J Nat Prod. 2010 Jan;73(1):55-9. doi: 10.1021/np900650c.
Taridaporn Bunyapaiboonsri 1,  Seangaroon Yoiprommarat,  Prasert Srikitikulchai,  Kitlada Srichomthong,  Saisamorn Lumyong
Affiliations

Affiliation

  • 1 National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Phahonyothin Road, Klong 1, Klong Luang, Pathumthani 12120, Thailand. taridaporn@biotec.or.th
PMID: 20038128 DOI: 10.1021/np900650c
Abstract

Six new oblongolides, W1, W2, X, Y, and Z (1-3, 6, 7) and 2-deoxy-4alpha-hydroxyoblongolide X (4), and the known compounds oblongolide (8), oblongolides T, C, and Q (5, 9, 10), and (-)-5-methylmellein were isolated from the endophytic fungus Phomopsis sp. BCC 9789. Compound 7 showed anti-HSV-1 activity (IC50=14 microM) and cytotoxic activities against KB, BC, NCI-H187, and nonmalignant (Vero) cell lines with respective IC50 values of 37, 26, 32, and 60 microM. Cytotoxic activity against the BC cell line was also observed for compound 6, with an IC50 value of 48 microM.

Figures